A Kehagias and P. N. Vlachos* (Greece), pvla@ac.anatolia.edu.gr Computer Aided Instruction for Business Calculus in an International Liberal Arts College In this paper we present a Computer Aided Instruction project that was conducted at the American College of Thessaloniki, Greece. Using a formal controlled experiment, we assess the efficiency of a computer based designed course (Laboratory setting, use of MathCad electronic notes specifically prepared for the course, Web Based system for dissemination of information etc.) in enhancing the understanding of important mathematical concepts, in improving overall performance and in making mathematics more interesting and attractive for students. The assessment of the experiment is based on both statistical hypothesis testing and analysis of qualitative data (perception questionnaires, etc.)